Infections caused by bacteria that are resistant to antibiotics are a major global health threat. A European study found that the biggest health burden comes from infections with three types of antibiotic-resistant bacteria: E. coli resistant to third-generation cephalosporins (3GCR), MRSA, and K. pneumoniae resistant to third-generation cephalosporins (3GCR). In Finland, these same bacteria are also causing the most problems. This project focuses on tackling these antibiotic resistance challenges in Finland. Specifically, it looks at: 1. 3GCR E. coli and K. pneumoniae in hospital-acquired bloodstream infections. 2. Livestock-Associated MRSA (LA-MRSA), which can contribute to human MRSA cases. In the study whole genome sequencing (WGS) is used to get detailed genetic information about these bacteria. This will help understanding the diversity and resistance mechanisms of the bacteria causing bloodstream infections. The data will be used to design better infection control protocols in hospitals, optimize treatment strategies, and reduce the spread of high-risk clones. Additionally, the project will study the genetic relationships between MRSA strains found in humans and pigs to assess the risk of transmission from pigs to humans. The findings will help develop strategies to reduce this risk, such as improving personal protection for people working with pigs.

2025

2027