Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury

Kuvaus

Abstract Background It is known that blood levels of neurofilament light (NF-L) and diffusion-weighted magnetic resonance imaging (DW-MRI) are both associated with outcome of patients with mild traumatic brain injury (mTBI). Here, we sought to examine the association between admission levels of plasma NF-L and white matter (WM) integrity in post-acute stage DW-MRI in patients with mTBI. Methods Ninety-three patients with mTBI (GCS ≥ 13), blood sample for NF-L within 24 h of admission, and DW-MRI ≥ 90 days post-injury (median = 229) were included. Mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from the skeletonized WM tracts of the whole brain. Outcome was assessed using the Extended Glasgow Outcome Scale (GOSE) at the time of imaging. Patients were divided into CT-positive and -negative, and complete (GOSE = 8) and incomplete recovery (GOSE < 8) groups. Results The levels of NF-L and FA correlated negatively in the whole cohort (p = 0.002), in CT-positive patients (p = 0.016), and in those with incomplete recovery (p = 0.005). The same groups showed a positive correlation with mean MD, AD, and RD (p < 0.001—p = 0.011). In CT-negative patients or in patients with full recovery, significant correlations were not found. Conclusion In patients with mTBI, the significant correlation between NF-L levels at admission and diffusion tensor imaging (DTI) measurements of diffuse axonal injury (DAI) over more than 3 months suggests that the early levels of plasma NF-L may associate with the presence of DAI at a later phase of TBI.
Näytä enemmän

Julkaisuvuosi

2023

Aineiston tyyppi

Tekijät

Department of Neuroscience and Biomedical Engineering

David K. Menon - Tekijä

Henna-Riikka Maanpää - Tekijä

Henrik Zetterberg - Tekijä

Iftakher Hossain - Tekijä

Jussi Hirvonen - Tekijä

Jussi P. Posti - Tekijä

Jussi Tallus - Tekijä

Kaj Blennow - Tekijä

Mark van Gils - Tekijä

Mehrbod Mohammadian - Tekijä

Olli Tenovuo - Tekijä

Peter Hutchinson - Tekijä

Riikka S. K. Takala - Tekijä

Timo Kurki - Tekijä

Timo Roine Orcid -palvelun logo - Tekijä

Virginia F. Newcombe - Tekijä

Tampere University - Muu tekijä

Turku University Hospital - Muu tekijä

University of Cambridge - Muu tekijä

University of Turku - Muu tekijä

figshare - Julkaisija

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Avoin

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Creative Commons Nimeä 4.0 Kansainvälinen (CC BY 4.0)

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