Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus: experimental data, computational model results, and files to generate the models

Kuvaus

Post-traumatic osteoarthritis is a musculoskeletal disorder where inflammatory processes and abnormal joint loading predispose articular cartilage to degradation after a mechanical injury. Since inflamed and injured cartilage cannot be reversed back to healthy state, prevention of osteoarthritis progression is advisable, a prestigious goal where computational models could serve as tools. The current literature is short of computational models combining both biochemical and biomechanical aspects of osteoarthritis. Thus, here we implemented inflammation of living cartilage tissue followed by biochemical perturbations of tissue homeostasis and shear strain-induced biomechanical degradation in novel cell-to-tissue-level finite element models. The models presented in this paper and enriched by our experimental findings/previous literature provide profound new mechanobiological insights and predictions about cartilage degradation in injured and inflamed tissue under physiologically relevant mechanical loading. We suggest that mechanobiological computational models could be applied as in silico analysis tools that provide clinicians information of the personalized progression of post-traumatic osteoarthritis and decision-making guidance for treatment of the disease. This dataset includes experimental data on cartilage degeneration obtained with digital densitometry (optical density near and away from chondral lesions), results from finite element models (loss of fixed charge density due to inflammation and biomechanical degradation), and the files needed to run the computational models.
Näytä enemmän

Julkaisuvuosi

2020

Aineiston tyyppi

Tekijät

Itä-Suomen yliopisto

Atte Eskelinen Orcid -palvelun logo - Julkaisija, Tekijä

Gustavo Orozco - Muu tekijä

Petri Tanska - Muu tekijä

Petro Julkunen - Muu tekijä

Rami Korhonen - Muu tekijä

Massachusetts Institute of Technology

Alan Grodzinsky - Muu tekijä

Cristina Florea - Muu tekijä

Projekti

Muut tiedot

Tieteenalat

LUONNONTIETEET; Biokemia, solu- ja molekyylibiologia; Lääketieteen tekniikka; LÄÄKE- JA TERVEYSTIETEET; Lääketieteen bioteknologia

Kieli

Saatavuus

Avoin

Lisenssi

Creative Commons Nimeä 4.0 Kansainvälinen (CC BY 4.0)

Avainsanat

articular cartilage, finite element analysis, fixed charge density, inflammation, Osteoarthritis, shear strain

Asiasanat

Ajallinen kattavuus

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