Data Management Plan for Academy of Finland, 27.09.2016 This project will investigate the effect of birth asphyxia as a risk factor for mental disorders on the functional development of the serotonergic system in an animal model. Using most electrophysiological measurements, I will address if birth asphyxia increases the firing activity of serotonergic neurons and alters how serotonin release is controlled. I will test if this is mediated by the activation of the stress axis by birth asphyxia and the resulting hyperelevated levels of the stress hormone arginine vasopressin. Finally, I will explore if birth asphyxia alters long-range interactions in the developing brain and if these could be mediated by altered serotonergic tone. The data I will collect are mostly time series of brain activity in vitro and in vivo which will generate large volumes of data. I will analyse these with appropriate methods to answer the questions as mentioned above.

2019